Anti-Obesity Potential of Sargassum horneri and Ulva australis Extracts: Study In Vitro and In Vivo

Current research highlights the use of natural products or phytochemicals as drugs and functional additives to treat obesity with few side effects. Sargassum horneri (SH) Ulva australis (UA) are marine waste resources on Jeju Island, Republic Korea. In this study, we analyzed their antioxidant anti-obesity efficacies confirm potential additives. We prepared SH UA extracts using 80% ethanol observed that free radical scavenging activity total phenol content were high in extracts, flavonoid was elevated extracts. Additionally, 3T3-L1 cells treated ability inhibit adipocyte differentiation examined Oil Red O staining analysis neutral fat content. confirmed mRNA expression C/EBPα, PPARγ, SREBP1c genes act differentiation, FAS, a fatty acid synthase, suppressed. Experiments mouse model showed 12-week administration high-fat diet 1% extract added drinking water resulted lower weight gain compared alone. These results suggest have properties effective prevention. Therefore, two additive candidates for preventing obesity.